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FIGURE 23-3 Charge-dipole potential energy depends on the orientation of the dipole
ABSENCE OF THE CRITERIA SEEN IN A MELANOCYTIC LESION
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// Write and then read back binary data. using System; using System.IO; class RWData { static void Main() { BinaryWriter dataOut; BinaryReader dataIn; int i = 10; double d = 1023.56; bool b = true; try { dataOut = new BinaryWriter(new FileStream("testdata", FileMode.Create)); } n exception is an error that occurs at runtime. Using C# s exception-handling subsystem, you can, in a structured and controlled manner, handle runtime errors. A principal advantage of exception handling is that it automates much of the errorhandling code that previously had to be entered by hand into any large program. For example, in a computer language without exception handling, error codes must be returned when a method fails, and these values must be checked manually each time the method is called. This approach is both tedious and error-prone. Exception handling streamlines errorhandling by allowing your program to define a block of code, called an exception handler, that is executed automatically when an error occurs. It is not necessary to manually check the success or failure of each specific operation or method call. If an error occurs, it will be processed by the exception handler. Exception handling is also important because C# defines standard exceptions for common program errors, such as divide-by-zero or index-out-of-range. To respond to these errors, your program must watch for and handle these exceptions. In the final analysis, to be a successful C# programmer means that you are fully capable of navigating C# s exceptionhandling subsystem. gene or multidrug resistance 3 (MDR3) gene (encoding for a canalicular phospholipid translocator) may be involved in ICP What hormonal factors may be involved in the pathogenesis of ICP What is the cardinal clinical manifestation of ICP that helps distinguish this disease from other liver conditions What do laboratory values reveal in patients with ICP High concentrations of estrogen and excess progesterone may be risk factors for ICP Severe pruritis (especially on the palms and soles of the feet) (Jaundice is present 10% of the time; jaundice without pruritis warrants other causes of liver disease.) Increased serum total bile acids (chenodeoxycholic acid, deoxycholic acid, cholic acid) Marked elevation of the cholic/ chenodeoxycholic acid ratio Elevated alkaline phosphatase Elevated total and direct bilirubin Elevated AST and ALT Normal prothrombin time (usually) What are the main liver conditions that must be ruled out Hepatitis (autoimmune and viral) Biliary tract disease Acute fatty liver of pregnancy HELLP syndrome What is the treatment of ICP Treatment is focused on relieving symptoms and preventing maternal and fetal complications. Ursodeoxycholic acid (500 mg bid until delivery) has been shown to alleviate pruritis and normalize bile acids and improve liver function test results. Early delivery (36 38 weeks) improves symptoms in majority of patients suffering from ICP Can oral contraceptives that contain estrogen be given postpartum Yes. Oral contraceptives containing low-dose estrogen can be given after normalization of liver function tests. Women should be advised of a potential recurrence of pruritis Fetal death Spontaneous preterm birth Postpartum hemorrhage
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