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Each of the two strands of a cdDNA are themselves continuous, closed circles. But because of the intertwining of the double helix, the two strands are linked to one another like two links in a chain. Figure 10-21 illustrates two closed curves as a way of representing the two circular strands of DNA in a cdDNA molecule. The figure shows the two curves linked together one, two, and six times. Although the links of a chain are typically linked together only once, two intertwining, circular strands can wrap around each more than once. The number of times that one strand is linked to the other strand is called the linking number and is denoted by Lk. The linking number is a topological invariant; it does not change under continuous changes of shape. Only if one or both of the DNA strands is broken (a noncontinuous, or discontinuous, change of shape) can the linking number change. In the field of topology, regarding linked curves, there are two more parameters that are directly useful for studying and understanding closed duplex DNA. The first is twist, denoted by Tw. The twist is the number of times one curve wraps around the other along the entire length of the curves. For the curves shown in Fig. 10-21, the twist is exactly equal to the linking number. Whenever the twist is equal to the linking number, then the two curves (except to the extent that they twist around each other) will lie entirely within a plane use asp .net barcode writer to use barcode in visual basic.net resolution BusinessRefinery.com/barcodehow to print barcode in asp net c# using backcolor .net to develop bar code with asp.net web,windows application BusinessRefinery.com/barcodeTCP/IP Internet Protocols .net barcode scanner sdk Using Barcode scanner for locate .NET Control to read, scan read, scan image in .NET applications. BusinessRefinery.com/barcodeusing copy visual .net crystal report to incoporate barcode on asp.net web,windows application BusinessRefinery.com/ barcodesLaser Scanning in Medical Renovation Work
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The basic ITU-T Recommendation G.729 specifies a speech coder that operates at 8 Kbps. This coder uses input frames of 10 milliseconds, corresponding to 80 samples at a sampling rate of 8,000 Hz. G.729 also includes a 5-millisecond look-ahead, resulting in an algorithmic delay of 15 milliseconds (significantly better than G.723.1). From each input frame, the coder determines linear prediction coefficients, excitation codebook indices, and gain parameters. These pieces of information are transmitted to the far end in 80-bit frames. Given that the input signal corresponds to 10 milliseconds of speech and results in a transmission of 80 bits, the transmitted bit rate is 8 Kbps. G.729 offers an MOS of about 4.0. Figure 3-9 shows a high-level block diagram of the G.729 encoder. G.729 Annex A G.729 is a complex codec. In order to reduce the complexity in the algorithm, a number of simplifications were introduced in Annex A to G.729. These include simplified codebook search routines and a simplification to the postfilter at the decoder among other things. G.729A uses exactly the same transmitted frame structure as G.729 and therefore uses the same bandwidth. In other words, the encoder may be operating according to G.729, while the decoder may operate using G.729A or vice versa. Note that G.729A can result in slightly lower quality than G.729. G.729A provides a MOS of about 3.7. G.729 Annex B Annex B to G.729 is a recommendation for voice activity detection (VAD), discontinuous transmission (DTX), and comfort noise generation (CNG). VAD is simply the decision as to whether voice or noise is present at the input. The decision is based on an analysis of several parameters of the input signal. Note that the determination is not done simply on the basis of one frame; rather, the determination is made on the basis of the current frame, plus the preceding two frames. This mechanism ensures that transmission occurs for at least two frames after a person has stopped speaking. The next decision is whether to send nothing at all or to send a SID frame. The SID frame contains some information to enable the decoder to +123 +1.232300e+002 +123 +1.23e+002 ######+123 +1.23e+002
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