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Note: In the examples in this chapter, we'll double each forward slash in HREF strings so that we can pass those strings directly to the Java URL class constructor. In practice, you are free to set up HREF strings as you like in your applications; usually, you use single, not double, slashes.
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Even though the transport capacity of the renal cortex is huge, it is not infinite. There are upper limits to the speed with which any given solute can be reabsorbed from the tubular lumen to capillary blood. In certain situations, these limits are reached, with the consequence that more than the usual amount of solute is not reabsorbed (ie, left in the lumen to be passed on to the next nephron segment). In general, transport mechanisms can be classified by the properties of these limits as either (1) tubular maximum-limited (Tm) systems or (2) gradient-limited systems. Tm systems reach an upper limit because the transporters moving the substance become saturated; any further increase in solute concentration does not increase the rate at which the substance binds to the transporter and thereafter moves through the membrane. Gradient-limited systems reach an upper limit because the tight junctions are leaky, and any significant lowering of luminal concentration relative to the interstitium results in a leak back into the lumen as fast as the substance is transported out. Thus, the upper rate for the Tmlimited system is a property of the transporter, whereas the upper rate of a gradient-limited system is a property of the permeability of the epithelial monolayer regardless of the maximal rate of the transport protein. Let us explain Tm-limited systems using glucose as an example. Glucose is present in plasma at a concentration of about 5 mmol/L (90 mg/dL) and is freely filtered. It is reabsorbed by the transcellular route. Glucose enters the epithelial cells across the apical membrane via a symporter with sodium (a member of the SGLT protein family) and exits across the basolateral membrane into the interstitium via a uniporter (a GLUT protein family member). Normally, all the filtered glucose is reabsorbed in the proximal tubule, with none remaining in the lumen to be passed on to the loop of Henle. However, if the filtered load of glucose is abnormally high, the SGLT proteins upper limit for reabsorption is reached. That upper limit is the tubular maximum, or Tm, for glucose. It is the maximum rate at which the substance (glucose in this case) can be reabsorbed regardless of the luminal concentration. Any increase in filtered load above the Tm, which for glucose
Use the subnet mask to include all computers
To open the Program Compatibility Wizard
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8.1 Biomass Fuels / 223 8.1.1 Feedstock Types / 224 8.1.2 Feedstock Properties / 227 8.2 The Chemistry of Biomass / 228 8.3 Processes / 231 8.3.1 Process Types / 231 8.3.2 Environmental Issues / 240 8.4 Fuels from Biomass / 241 8.4.1 Gaseous Fuels / 242 8.4.2 Liquid Fuels / 244 8.4.3 Solid Fuels / 248 8.4.4 Biofuels from Synthesis Gas / 249 8.5 Uses / 250 8.6 A Biorefinery / 251 8.6.1 Bioconversion / 252 8.6.2 Thermal Conversion / 254 8.6.3 Greenhouse Gas Production / 257 8.6.4 Other Aspects / 257 8.7 The Future / 259
8 On the User Permissions page, select the accounts that can connect over the
Please note that console applications are still executed in Windows but in the console.
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