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15: Molecular Evolution 233
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My Genome s Bigger than Your Genome! 234 Genome sizes at a glance 234 The C value and the C-value paradox 236 Distinguishing between genes and non-coding DNA 236 The Whys and Wherefores of Non-coding DNA 238 It performs a function 238 It serves no function but isn t harmful 239 It s parasitic!239 Coding DNA: Changing the Number of Genes an Organism Has 240 Getting genes from other lines: Lateral gene transfer 240 Shuffling exons: Alternative gene splicing 241 Duplicating genes: A gene is born 242 The Neutral Theory of Molecular Evolution243 Telling Time with Genes: The Molecular Clock 244 When you can t 244 When you can 244
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Table of Contents
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Part IV: Evolution and Your World 249
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16: Human Evolution 251
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The Origin of Homo Sapiens: Where We Came From251 Phylogenetic evidence: Hangin round on the Tree of Life 252 Carved in stone: The fossils254 Reconstructing the history of hominid evolution257 Out of Africa: Hominid migration patterns 261 Evolution within Homo Sapiens 265 Natural selection: Still acting on humans265 Relaxation of selection 267 Cultural evolution267
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17: The Evolution of Antibiotic Resistance 269
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Antibiotics and Antibiotic Resistance in a Nutshell 270 Splitting microbial hairs: Defining antibiotics 270 A brief history of antibiotic resistance271 Becoming Resistant to Antibiotics: A How-to Guide 272 Evolution via mutation 273 Evolution via gene transfer 274 Resistance at the cellular and biochemical levels 275 Evolving a bit at a time: Partial resistance276 The Battle against Antibiotic Resistance 277 New and improved! Making new drugs277 Turning back the clock to bacterial sensitivity 278 Changing the way antibiotics are used281
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18: HIV: The Origin and Evolution of a Virus 283
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What Viruses Are284 Are viruses alive We say Yes! 284 Viral reproduction: DNA, RNA, or retro 286 What Is HIV 286 Sneaking around in your chromosome287 Attacking T cells 287 Mutating like crazy288 The History of the HIV Epidemic 288 Where it came from289 A timeline290 The Path and Evolution of HIV in the Patient291 Increasing and growing more divergent 292 Reaching a plateau 293 Destroying T-cells in a different way293
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Evolution For Dummies
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Other Interesting Facts about HIV 294 Some people may be resistant294 HIV evolves in a new host 294 HIV has a high recombination rate 295 Using Evolution to Fight HIV295
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19: Influenza: One Flu, Two Flu, Your Flu, Bird Flu 297
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The Flu and Your Immune System 298 Act 1: The virus attacks and spreads298 Act 2: The body fights back 298 Act 3: Building up the guard299 Which leads to a sequel: The return of the flu 299 The Three Types of Influenza: A, B, C299 The Evolution of Influenza A300 Mechanisms of evolution: Mutation, recombination, or reassortment 300 Genes to know 301 Who gets the flu and from where 302 Learning from the Past: Flu Pandemics305 Pandemics of 1889 and 1900 306 The Spanish flu (1918) 306 The Asian flu (1957) 306 The Hong Kong flu (1968)307 The Russian flu (1977) 307 Fighting Back: The Art and Science of Making Flu Vaccines308 Dead vaccines 308 Live vaccines309 Predicting the future to make next year s vaccine311 Making a more universal influenza A vaccine313
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Part V: The Part of Tens 315
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20: Ten Fascinating Fossil Finds 317
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Dinosaurs 317 Archaeopteryx319 Wrangle Island Mammoths 320 Pterosaurs (Pterodactyls)320 Trilobites 321 Tiktaalik Rosea 322 Hallucigenia and the Burgess Shale 323 Stromatolites 324 Microfossils325 Amber 326
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Table of Contents 21: Ten Amazing Adaptations 327
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Different Kinds of Teeth 327 Sight: The Evolution of the Eye 328 Cave Blindness 329 Back to the Sea 330 And Back to the Land Again331 Photosynthesis332 Deep-Sea Thermal-Vent Organisms332 Endosymbiosis 333 Vertebrate Flight333 Trap-jaw Ants334
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xvii
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22: Ten Arguments against Evolution and Why They re Wrong 335
It s Only a Theory335 It Violates the Second Law of Thermodynamics336 It s Been Proved Wrong (by Scientists!) 336 It s Completely Random 337 It Can t Result in Big Changes338 No Missing Link Means No Proof 338 It Can t Account for Everything: Enter the Intelligent Designer339 It Can t Create Complex Structures 340 It Should Be Taught with ID in Science Class 341 It s a Fringe Topic 342 It s at Odds with Biblical Creation 343
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